James E Zadina
Professor at Medicine, Tulane University of Louisiana0 Followers
Dr. James E. Zadina holds a distinguished position at the Tulane School of Medicine, where he serves as a Professor across three key areas: Medicine, Pharmacology, and Neuroscience. Beyond his professorial duties, he also directs the Neuroscience Laboratory at the Southeast Louisiana Veterans Health Care System, bringing his expertise to support veteran health. His deep engagement with medical science is further highlighted by his affiliations with both the Tulane Center on Aging and the Department of Pharmacology, reflecting a broad commitment to advancing understanding in these vital fields.
At the heart of Dr. Zadina's research lies a dedicated focus on the intricate neurobiology of opioids. He is particularly driven to find better ways to manage pain while simultaneously addressing the significant challenges associated with opioid use, such as addiction and abuse. His innovative approach centers on developing new pain relief medications that are not only effective but also inherently safer than the traditional opioids currently available. This involves a fascinating process of modifying naturally occurring opioids, especially a group known as endomorphins, a line of inquiry that has shown considerable promise in initial studies.
His pioneering work has yielded truly exciting results in preclinical settings. These studies have compellingly shown that the modified endomorphins he has developed can provide pain relief that is comparable to, or even surpasses, the effects of morphine. Crucially, this potent pain relief comes with significantly fewer side effects and a substantially lower potential for abuse. This body of work offers a beacon of hope for the future of pain management, suggesting the possibility of revolutionary new therapies that could dramatically improve the lives of those suffering from chronic pain and help mitigate the widespread impact of opioid addiction.
Beyond the realm of pain relief itself, Dr. Zadina is also actively exploring how his research might be applied to help those struggling with opioid use disorder. His efforts in this area are aimed at opening up new therapeutic pathways, offering individuals battling addiction more effective and sustainable options on their journey toward recovery.
Dr. Zadina's significant contributions to the fields of neuroscience and pharmacology have not gone unnoticed. His work is widely recognized, evidenced by his extensive list of publications and frequent presentations at both national and international conferences. His unwavering dedication to improving patient outcomes and pushing the boundaries of scientific knowledge continues to be a driving force behind his research, serving as a source of inspiration for his colleagues and the next generation of students alike.
External Link tulane.edu/ At the heart of Dr. Zadina's research lies a dedicated focus on the intricate neurobiology of opioids. He is particularly driven to find better ways to manage pain while simultaneously addressing the significant challenges associated with opioid use, such as addiction and abuse. His innovative approach centers on developing new pain relief medications that are not only effective but also inherently safer than the traditional opioids currently available. This involves a fascinating process of modifying naturally occurring opioids, especially a group known as endomorphins, a line of inquiry that has shown considerable promise in initial studies.
His pioneering work has yielded truly exciting results in preclinical settings. These studies have compellingly shown that the modified endomorphins he has developed can provide pain relief that is comparable to, or even surpasses, the effects of morphine. Crucially, this potent pain relief comes with significantly fewer side effects and a substantially lower potential for abuse. This body of work offers a beacon of hope for the future of pain management, suggesting the possibility of revolutionary new therapies that could dramatically improve the lives of those suffering from chronic pain and help mitigate the widespread impact of opioid addiction.
Beyond the realm of pain relief itself, Dr. Zadina is also actively exploring how his research might be applied to help those struggling with opioid use disorder. His efforts in this area are aimed at opening up new therapeutic pathways, offering individuals battling addiction more effective and sustainable options on their journey toward recovery.
Dr. Zadina's significant contributions to the fields of neuroscience and pharmacology have not gone unnoticed. His work is widely recognized, evidenced by his extensive list of publications and frequent presentations at both national and international conferences. His unwavering dedication to improving patient outcomes and pushing the boundaries of scientific knowledge continues to be a driving force behind his research, serving as a source of inspiration for his colleagues and the next generation of students alike.
Publications
2 - Role Of Nitric Oxide In Mediating Vasodilator Responses To Opioid Peptides In The Rat,Clinical and Experimental Pharmacology and Physiology
Hunter C Champion , Trinity J Bivalacqua , James E Zadina , Abba J Kastin , Albert L Hyman , Philip J Kadowitz ,
, 229-232, 2002-03-01
3 - Phe13, Tyr19‐Melanin‐Concentrating Hormone and the Blood—Brain Barrier,Journal of Neurochemistry
4 - Endomorphin‐1 and ‐2 immunoreactive cells in the hypothalamus are labeled by fluoro‐gold injections to the ventral tegmental area,Journal of Comparative Neurology
Thomas N. Greenwell , Abraham Zangen , Sheryl Martin‐Schild , Roy A. Wise , James E. Zadina ,
, 320-328, 2002-11-19
5 - Tests Used to Assess the Cognitive Abilities of Aged Rats: Their Relation to Each Other and to Hippocampal Morphology and Neurotrophin Expression,Gerontology
RobertN. McLay , ScottM. Freeman , RichardE. Harlan , AbbaJ. Kastin , JamesE. Zadina ,
, 143-155, 1999-01-01
7 - Melanocyte‐Stimulating Hormone Release‐Inhibiting Factor‐1 (MIF‐1) Can Be Formed from Tyr‐MIF‐1 in Brain Mitochondria but Not in Brain Homogenate,Journal of Neurochemistry
Abba J. Kastin , Kathy Hahn , James E. Zadina , William A. Banks , Laszlo Hackler ,
, 1855-1859, 1995-04-01
9 - Endomorphins inhibit high‐threshold Ca2+ channel currents in rodent NG108‐15 cells overexpressing μ‐opioid receptors,The Journal of Physiology
Haruhiro Higashida , Naoto Hoshi , Rimma Knijnik , James E. Zadina , Abba J. Kastin ,
, 71-75, 1998-02-01
12 - Colocalization and shared distribution of endomorphins with substance P, calcitonin gene‐related peptide, γ‐aminobutyric acid, and the mu opioid receptor,Journal of Comparative Neurology
Thomas N. Greenwell , Sheryl Martin‐Schild , Fiona M. Inglis , James E. Zadina ,
, 319-333, 2007-05-09
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