Jefferson Chan

Professor at Pathology and Laboratory Medicine, University of California-Irvine0 Followers

Dr. Jefferson Chan is a renowned researcher in the field of pathology, serving as a Professor at the UCI School of Medicine. Situated at 1001 Health Sciences Road in Irvine, California, Dr. Chan's work is integral to the academic and scientific community at the University of California-Irvine. His contributions to pathology and laboratory medicine are well-regarded, reflecting his commitment to advancing medical knowledge and education. While specific research interests are not detailed, Dr. Chan's role at UCI underscores his significant impact on the field, fostering a deeper understanding of pathology through both teaching and research.

Research Interests

Pathology laboratory medicine medical education disease mechanisms

Publications

1 - Deficiency in the nuclear‐related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability,The FEBS Journal

Diane H. Oh , Diamanda Rigas , Ara Cho , Jefferson Y. Chan ,

, 4121-4130, 2012-10-04

2 - Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice,Physiological Genomics

Jonghyun Kim , Weirong Xing , Jon Wergedal , Jefferson Y. Chan , Subburaman Mohan ,

, 100-110, 2010-01-01

3 - Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction,Biochemical Journal

Qiang MA , Krista KINNEER , Yongyi BI , Jefferson Y. CHAN , Yuet Wai KAN ,

, 205-213, 2004-01-01

4 - Loss of Nrf1 Function in the Brain Causes Age‐Dependent Neurodegeneration,The FASEB Journal

Candy Shih‐Chi Lee , Jefferson J Chan ,

, 2009-04-01

5 - Development of Nitroreductase‐Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding,Helvetica Chimica Acta

Zhenxiang Zhao , Anuj K. Yadav , Yourong Weng , Jefferson Chan ,

, 2023-09-13

6 - A biomimetic approach to promote cellular uptake and enhance photoacoustic properties of tumor-seeking dyes,

Amanda East , Michael Lee , Chang Jiang , Qasim Sikander , Jefferson Chan ,

, 2022-12-16

7 - Nuclear factor‐erythroid 2‐related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice,The FEBS Journal

Candy S. Lee , Daniel V. Ho , Jefferson Y. Chan ,

, 3609-3620, 2013-06-18

8 - Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice,Blood

Jefferson Y. Chan , Mandy Kwong , Margaret Lo , Renee Emerson , Frans A. Kuypers ,

, 2151-2158, 2001-04-01

9 - Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic stem cell depletion,

Zhenxiang Zhao , Melissa Lucero , Shengzhang Su , Jiajie Jessica Xu , Jefferson Chan ,

, 2023-09-08

10 - GSK3 negatively regulates stress response mediated by transcription factor Nrf1, resulting in increased neuronal apoptosis and neurodegeneration,The FASEB Journal

Madhurima Biswas , Jefferson Y. Chan ,

, 2012-04-01

11 - Towards Personalized Medicine: Photoacoustic Imaging of Glutathione Enables Companion Diagnosis and Targeted Treatment of Lung Cancer,

Melissa Lucero , Jefferson Chan ,

, 2020-04-28

12 - Fortschritte bei aktivitätsbasierten Sonden für die isoformselektive Bildgebung enzymatischer Aktivität,Angewandte Chemie

Sarah H. Gardner , Christopher J. Reinhardt , Jefferson Chan ,

, 5052-5062, 2020-09-11

13 - Towards Personalized Medicine: Photoacoustic Imaging of Glutathione Enables Companion Diagnosis and Targeted Treatment of Lung Cancer,

Melissa Lucero , Jefferson Chan ,

, 2020-04-28

14 - Towards Personalized Medicine: Photoacoustic Imaging Enables Companion Diagnosis and Targeted Treatment of Lung Cancer,

Melissa Lucero , Jefferson Chan ,

, 2020-02-24

15 - Advances in Activity‐Based Sensing Probes for Isoform‐Selective Imaging of Enzymatic Activity,Angewandte Chemie International Edition

Sarah H. Gardner , Christopher J. Reinhardt , Jefferson Chan ,

, 5000-5009, 2020-09-11

16 - Induction of Herpud1 expression by ER stress is regulated by Nrf1,FEBS Letters

Daniel V. Ho , Jefferson Y. Chan ,

, 615-620, 2015-01-28

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